| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Ben Edlund | Crew | Writing | Writer, Original Story, Story | 1 |
 Christopher McCulloch | Crew | Production | Producer, Writer, Director, Story, Creator | 63 |
 Doc Hammer | Crew | Writing | Writer, Original Story, Creator | 52 |
 J.G. Thirlwell | Crew | Sound | Original Music Composer | 81 |
 Jon Schnepp | Crew | Directing | Co-Director | 8 |
 Juno John Lee | Crew | Directing | Director | 12 |
 Keith Crofford | Crew | Production | Executive Producer | 81 |
 Barry J. Kelly | Crew | Directing | Co-Director | 10 |
 Bill Hader | Cast | Actor | Professor Impossible / Alien villain (voice) | 1 |
 Brendon Small | Cast | Actor | Resistance 1 (voice) | 1 |
 Charles Parnell | Cast | Actor | Jefferson Twilight (voice) | 1 |
Christopher McCulloch | Cast | Actor | Hank Venture / The Monarch (voice) | 81 |
 Dana Snyder | Cast | Actor | President Breyer (voice) | 1 |
Doc Hammer | Cast | Actor | Dr. Girlfriend / Henchman 21 (voice) | 81 |
 H. Jon Benjamin | Cast | Actor | The Master (voice) | 2 |
 J.K. Simmons | Cast | Actor | Ben (Old Man Potter) (voice) | 1 |
 James Urbaniak | Cast | Actor | Dr. Venture (voice) | 81 |
 Kevin Conroy | Cast | Actor | Captain Sunshine (voice) | 2 |
 Lisa Hammer | Cast | Actress | Triana Orpheus (voice) | 14 |
 Michael Sinterniklaas | Cast | Actor | Dean Venture (voice) | 81 |
 Misha Collins | Cast | Actor | Prisoner 2 / Maestro Wave (voice) | 1 |
 Nathan Fillion | Cast | Actor | Brown Widow (voice) | 1 |
 Patrick Warburton | Cast | Actor | Brock Samson (voice) | 81 |
 Patton Oswalt | Cast | Actor | Wonderboy (voice) | 1 |
 Paul Boocock | Cast | Actor | Priest 1 / Jonas Venture (voice) | 1 |
 Seth Green | Cast | Actor | Lance Hale / Mrs. Z (voice) | 1 |
 Stephen Colbert | Cast | Actor | Professor Impossible (voice) | 2 |
 Steve Park | Cast | Actor | Mike Sorayama (voice) | 1 |
 Toby Huss | Cast | Actor | General Treister (voice) | 2 |
 Cristin Milioti | Cast | Actress | Night Nurse Cindy Marie Abrams (voice) | 1 |
 Gillian Jacobs | Cast | Actress | Marsha Backwood (voice) | 1 |
 John Hodgman | Cast | Actor | Dale Hale (voice) | 1 |
 Steven Rattazzi | Cast | Actor | Dr. Orpheus (voice) | 31 |
| Person | Type | Job | Role(s) | Episodes |
