| Person | Type | Job | Role(s) |
|---|---|---|---|
 Kevin Peaty | Crew | Directing | Director |
Mark Banker | Crew | Writing | Writer |
 Dav Pilkey | Crew | Writing | Novel |
Matt Smith | Crew | Writing | Writer |
Seung Woo Cha | Crew | Directing | Director |
 Clancy Brown | Cast | Actor | Mr. Ree (voice) |
 David Koechner | Cast | Actor | Mr. Meaner (voice) |
 Erica Luttrell | Cast | Actress | Erica / George's Mom (voice) |
 Jorge Diaz | Cast | Actor | Melvin / Stanley Peet / Melvin's Dad (voice) |
 Kevin Michael Richardson | Cast | Actor | Diddlysaurus / George's Dad (voice) |
 Mindy Sterling | Cast | Actress | Melvin's Mom (voice) |
 Nat Faxon | Cast | Actor | Captain Underpants / Mr. Krupp (voice) |
 Peter Hastings | Cast | Actor | Comic Narrator (voice) |
 Sean Astin | Cast | Actor | Narrator / Mr Gigglenose (voice) |
 Stephen Tobolowsky | Cast | Actor | Creepy Rattlechains (voice) |
 Kari Wahlgren | Cast | Actress | Mayor Hoppy McChapper (voice) |
 Dayci Brookshire | Cast | Jessica / Dressy (voice) | |
 Brennan Murray | Cast | Actor | Bo Hweemuth (voice) |
 Evan Kishiyama | Cast | Steve "Gooch" Yamaguchi (voice) | |
 Ramone Hamilton | Cast | Actor | George (voice) |
 Jay Gragnani | Cast | Actor | Harold (voice) |
 Patty Mattson | Cast | Miss Anthrope / Harold's Mom (voice) | |
| Person | Type | Job | Role(s) |
