| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Jude Law | Crew | Production | Executive Producer | 9 |
 Lele Marchitelli | Crew | Sound | Original Music Composer | 9 |
 Luca Bigazzi | Crew | Camera | Director of Photography | 9 |
 Paolo Sorrentino | Crew | Production | Executive Producer, Director, Writer, Creator | 9 |
Riccardo Neri | Crew | Production | Executive Producer | 9 |
 Umberto Contarello | Crew | Writing | Writer | 9 |
Cristiano Travaglioli | Crew | Editing | Editor | 9 |
 Stefano Bises | Crew | Writing | Writer | 9 |
Simone Coco | Crew | Visual Effects | Visual Effects Supervisor | 9 |
Matteo Menduni | Crew | Writing | Story Editor | 9 |
 Alessandro Riceci | Cast | Fabiano | 4 | |
 Antonio Petrocelli | Cast | Actor | Monsignor Luigi Cavallo | 6 |
 Christian Erickson | Cast | Actor | 3 | |
 Claudio Bigagli | Cast | Actor | Duilio Guicciardini | 3 |
 Cécile de France | Cast | Actress | Sofia Dubois | 9 |
 Francesca Cutolo | Cast | 1 | ||
 Guido Roncalli | Cast | 3 | ||
 Henry Goodman | Cast | Actor | Danny | 9 |
 Ignazio Oliva | Cast | Actor | Father Valente | 3 |
 Janet Henfrey | Cast | Actress | Lady Brannox | 2 |
 Javier Cámara | Cast | Actor | Cardinal Gutierrez | 9 |
 John Malkovich | Cast | Actor | Giovanni Paolo III / Sir John Brannox | 9 |
Jude Law | Cast | Actor | Pius XIII / Lenny Belardo | 9 |
 Kiruna Stamell | Cast | Actress | The Abbess | 6 |
 Lore Stefanek | Cast | Actress | Attanasio's Mother | 2 |
 Luciano Roffi | Cast | Actor | 3 | |
 Ludivine Sagnier | Cast | Actress | Esther | 9 |
 Marilyn Manson | Cast | Actor | Marilyn Manson | 1 |
 Marina Viro | Cast | Actress | Esther's Interviewer | 1 |
 Mark Ivanir | Cast | Actor | Bauer | 9 |
 Massimo Ghini | Cast | Actor | Cardinal Spalletta | 9 |
 Ramón García | Cast | Actor | Cardinal Aguirre | 6 |
Robert Brodie Booth | Cast | Actor | Reporter | 2 |
 Sergio Forconi | Cast | Actor | 3 | |
 Sharon Stone | Cast | Actress | Sharon Stone | 1 |
 Silvio Orlando | Cast | Actor | Cardinal Voiello | 9 |
 Tim Barlow | Cast | Actor | Lord Brannox | 2 |
 Tomas Arana | Cast | Actor | Thomas Altbruck | 4 |
 Ulrich Thomsen | Cast | Actor | Doctor Lindegard | 9 |
 Daniel Vivian | Cast | Actor | Domen | 2 |
 Marcello Marziali | Cast | Actor | Don Mimmo | 4 |
 Mitchell Mullen | Cast | Actor | Emory Kitsworth | 1 |
 Nora Waldstätten | Cast | Actress | Sister Lisette | 6 |
 Kika Georgiou | Cast | Actress | Donna Divisa Rossa | 6 |
 Massimo Cagnina | Cast | Don Mario | 5 | |
 Yuliya Snigir | Cast | Actress | Ewa Nowak | 1 |
 Emmanuel Dabone | Cast | 3 | ||
 Maurizio Lombardi | Cast | Actor | Cardinal Mario Assente | 9 |
 Tony Allotta | Cast | Califfo | 4 | |
 Alex Esola | Cast | Actor | Freddy Blakestone | 2 |
 J. David Hinze | Cast | Actor | Leopold Essence | 1 |
 Eco Andriolo Ranzi | Cast | Actress | Sister Caterina | 6 |
 Libero Sansavini | Cast | Actor | 3 | |
 Marcello Romolo | Cast | Actor | Tommaso Viglietti | 2 |
Nicolas Porcelli | Cast | Actor | Surgeon | 1 |
Nadee Kammellaweera | Cast | Actress | Sister Suree | 5 |
Enea Barozzi | Cast | Attanasio | 3 | |
 Matthew Smallwood | Cast | Young John Brannox | 5 | |
 Joshua Smallwood | Cast | Adam Brannox | 4 | |
 David Sebasti | Cast | 1 | ||
 Daria Baykalova | Cast | Actress | Bauer's Girlfriend | 3 |
Ian Sutton | Cast | 1 | ||
Osvaldo Alzari | Cast | Actor | 3 | |
Edoardo Bussi | Cast | Girolamo | 4 | |
Agnieszka Jania | Cast | Sister Ivanka | 4 | |
 Sinne Mutsaers | Cast | Sky Journalist | 1 | |
Calum Potts | Cast | John Brannox - 12 | 2 | |
Ahmed Ali Boutgoula | Cast | 1 | ||
Bea Maria Salvador | Cast | 1 | ||
Zaki Bibawi Ayyad | Cast | Faisal | 5 | |
John Henderson Howard | Cast | 1 | ||
Giorgio Isopi | Cast | 1 | ||
Giorgio Braschi | Cast | 1 | ||
 Michelangelo Tarditti | Cast | Actor | 3 | |
Michael Fitzpatrick | Cast | 3 | ||
 Nicolò Galasso | Cast | Franciscan | 2 | |
 Jessica Piccolo Valerani | Cast | Actress | Sister Pamela | 4 |
 Giulio Della Monica | Cast | Franciscan | 2 | |
Marcella Sacco | Cast | 1 | ||
Giampaolo Nerini | Cast | Priest | 2 | |
Gianluigi Calvani | Cast | Fraticello | 1 | |
Charlie Potts | Cast | Adam Brannox - 12 | 2 | |
Thomas Miggiano | Cast | Pius | 6 | |
Jonas Crodack | Cast | Young Lord Brannox | 3 | |
Hella Stichlmair | Cast | Young Lady Brannox | 3 | |
Mara Fronzi | Cast | 1 | ||
Evandro Inetti | Cast | Vatican Photographer | 2 | |
Alberto Rosini | Cast | 1 | ||
Enzo Samaritani | Cast | 1 | ||
Nicole Biscaro | Cast | 1 | ||
Valentina Bernabei | Cast | Actress | 1 | |
Chiara Mocci | Cast | Actress | Young Prostitute | 2 |
Houssem Benali | Cast | Ahmed | 1 | |
Giancarlo Fares | Cast | Girolamo's Caregiver | 1 | |
 Federica Corti | Cast | Actress | 2 | |
 Fabiola Cimminella | Cast | Ballerina | 1 | |
| Person | Type | Job | Role(s) | Episodes |
