| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Carmen Cuba | Crew | Production | Casting | 20 |
 Cliff Martinez | Crew | Sound | Original Music Composer | 20 |
 Clive Owen | Crew | Production | Executive Producer | 10 |
 David Kirchner | Crew | Production | Associate Producer | 10 |
Dennis Towns | Crew | Sound | Sound mixer | 10 |
 Ellen Mirojnick | Crew | Costume & Make-Up | Costume Design | 20 |
 Gregory Jacobs | Crew | Production | Executive Producer | 20 |
Henry Dunn | Crew | Art | Art Direction | 10 |
 Howard Cummings | Crew | Art | Production Design | 20 |
 Jack Amiel | Crew | Production | Executive Producer, Writer, Creator | 20 |
John Glaser | Crew | Costume & Make-Up | Assistant Costume Designer | 10 |
Laura Ballinger | Crew | Art | Art Direction | 10 |
 Michael Begler | Crew | Production | Executive Producer, Writer, Creator | 20 |
 Michael Polaire | Crew | Production | Producer | 10 |
 Michael Sugar | Crew | Production | Executive Producer | 10 |
Regina Graves | Crew | Art | Set Decoration | 20 |
 Steven Katz | Crew | Writing | Writer, Producer | 2 |
 Steven Soderbergh | Crew | Camera | Director of Photography, Editor, Executive Producer, Director | 20 |
Thomas Johnston | Crew | Directing | Script Supervisor | 10 |
Paul Molnar | Crew | Costume & Make-Up | Makeup Artist | 1 |
 Brian Kerwin | Cast | Actor | Corky | 1 |
 Bridget Barkan | Cast | Actress | Nora | 1 |
 Cara Seymour | Cast | Actress | Sister Harriet | 20 |
Clive Owen | Cast | Actor | Dr. John Thackery | 20 |
 Craig muMs Grant | Cast | Actor | Hernia Patient | 1 |
 Danny Hoch | Cast | Actor | Bunky Collier | 4 |
 David Fierro | Cast | Actor | Inspector Jacob Speight | 4 |
 Emily Bergl | Cast | Actress | Mrs. Hemming | 3 |
 Eric Johnson | Cast | Actor | Dr. Everett Gallinger | 20 |
 Frank Wood | Cast | Actor | Mr. Havershorn | 3 |
 Grainger Hines | Cast | Actor | Captain August Robertson | 5 |
 Johanna Day | Cast | Actress | Eunice Showalter | 2 |
 Jon Patrick Walker | Cast | Doctor at Orphanage | 1 | |
 Karl Bury | Cast | Actor | Mr. Corker | 1 |
Kim Rideout | Cast | Actress | Cornelia's Maid | 2 |
 Leon Addison Brown | Cast | Actor | Jesse Edwards | 5 |
 Matt Frewer | Cast | Actor | Dr. J.M. Christiansen | 2 |
 Melissa Errico | Cast | Actress | Catherine Christiansen | 3 |
 Michael Angarano | Cast | Actor | Dr. Bertram “Bertie" Chickering, Jr. | 20 |
 Michael Berresse | Cast | Actor | Parke Davis Rep. | 3 |
 Michael Nathanson | Cast | Actor | Dr. Levi Zinberg | 1 |
 Molly Price | Cast | Actress | Effie Barrow | 2 |
Monty Stuart | Cast | Actor | Pete | 1 |
 Perry Yung | Cast | Actor | Ping Wu | 2 |
 Peter Maloney | Cast | Actor | Barber / Doc | 1 |
 Reg Rogers | Cast | Actor | Dr. Bertram Chickering, Sr. | 2 |
 Suzanne Savoy | Cast | Actress | Victoria Robertson | 5 |
 Ylfa Edelstein | Cast | Actress | Nurse Baker | 2 |
 Zenon Zeleniuch | Cast | Actor | Slum Landlord | 1 |
 Adam Mucci | Cast | Actor | Dietz | 1 |
 David Neal Levin | Cast | Actor | Mr. Olynyk | 1 |
 David Wilson Barnes | Cast | Actor | Dr. Hackett | 1 |
 Eve Hewson | Cast | Actress | Lucy Elkins | 20 |
 Helen Coxe | Cast | Actress | Miss Carhart | 1 |
 Jennifer Ferrin | Cast | Actress | Abigail Alford | 2 |
 John Hodgman | Cast | Actor | Doctor Entrusted with Eleanor | 1 |
 Juliet Rylance | Cast | Actress | Cornelia Robertson | 20 |
 Lucas Papaelias | Cast | Actor | Eldon Pouncey | 5 |
 Maja Wampuszyc | Cast | Actress | Mrs. Zygmund | 1 |
 Rob Morgan | Cast | Actor | Diggs Man | 1 |
 Ryan Homchick | Cast | Actor | Orderly Schleif | 1 |
 Tom Papa | Cast | Actor | Luff | 1 |
 André Holland | Cast | Actor | Dr. Algernon Edwards | 20 |
 Brian Tyree Henry | Cast | Actor | Larkin | 1 |
 Chris Sullivan | Cast | Actor | Tom Cleary | 20 |
 Emily Kinney | Cast | Actress | Nurse Daisy Ryan | 3 |
 Happy Anderson | Cast | Actor | Jimmy | 4 |
 Jeremy Bobb | Cast | Actor | Herman Barrow | 20 |
 Maya Kazan | Cast | Actress | Eleanor Gallinger | 5 |
 Rachel Korine | Cast | Actress | Junia | 3 |
 Rob Michael Hugel | Cast | Mr. Gatchell | 3 | |
 Tom Lipinski | Cast | Actor | Phillip Showalter | 2 |
 Zuzanna Szadkowski | Cast | Actress | Nurse Pell | 7 |
 Cait Cortelyou | Cast | Actress | Nurse Monk | 2 |
 Danya LaBelle | Cast | Mrs. Lefkowitz | 1 | |
 Dean Neistat | Cast | Actor | McCarthy | 1 |
 Erin Wilhelmi | Cast | Actress | Lottie | 1 |
Pei Pei Lin | Cast | Actress | Chinese Prostitue | 1 |
Antwayn Hopper | Cast | Woodson | 1 | |
 Makenzie Leigh | Cast | Actress | Amy O'Connor | 2 |
 Phillip Chorba | Cast | Actor | Quinn | 1 |
 Victoria Leigh | Cast | Actress | Cora Hemming | 2 |
 Ying Ying Li | Cast | Lin-Lin | 9 | |
 Dominique Fishback | Cast | Actress | Black Girl | 1 |
 Henry Gagliardi | Cast | Actor | Krawetz Kid (uncredited) | 1 |
 Jonah Coppolelli | Cast | Actor | Paper Boy, Working Class Boy | 1 |
 Sawyer Barth | Cast | Actor | The Whispering Kid | 1 |
 Athan Sporek | Cast | Actor | Paulo (Street Urchin) | 1 |
Aija Terauda | Cast | Actress | Mrs. Krawetz | 1 |
 Kate Easton | Cast | Actress | Mrs. Warren | 1 |
 Clarke Thorell | Cast | Actor | McTeague | 1 |
 Ashley Bryant | Cast | Actress | Infirmary Nurse | 1 |
 Charles Aitken | Cast | Actor | Cornelia's Brother | 1 |
Alfred Cole | Cast | Actor | Prize Fighter | 1 |
 Rachel Izen | Cast | Actress | Nurse Braun | 1 |
 Pernell Walker | Cast | Actress | Ida Harris | 1 |
Christopher Dalbey | Cast | Bleier Driver | 1 | |
Erika Rolfsrud | Cast | Actress | Edwards' Patient's Mother | 1 |
 Edwin Lugo | Cast | Actor | Ernesto Mendieta | 1 |
 Andy Murray | Cast | Actor | Clarence Mulkeen | 1 |
 Noelle P. Wilson | Cast | Actress | Cromartie Nurse | 1 |
 Hamilton Bonita | Cast | Mrs.Gamble | 2 | |
 Arielle Goldman | Cast | Actress | Genevieve Everidge | 1 |
Tom Treadwell | Cast | Mr. Edison | 1 | |
 Melanie Brook | Cast | Actress | Frances | 2 |
 Collin Meath | Cast | Actor | Phinny Sears | 3 |
Mārtiņš Straupe | Cast | Mr. Krawetz | 1 | |
Christopher Clark Gates | Cast | Dr. Lyons | 1 | |
 LaTonya Borsay | Cast | Mrs. Edwards | 4 | |
| Person | Type | Job | Role(s) | Episodes |
