| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Jared Faber | Crew | Sound | Music | 39 |
John Matta | Crew | Writing | Writer | 1 |
Kevin Peaty | Crew | Directing | Director | 12 |
Mark Banker | Crew | Writing | Writer | 15 |
 Peter Hastings | Crew | Writing | Writer, Executive Producer | 1 |
Fred Kron | Crew | Sound | Music | 39 |
Paul Cheolsoo Lee | Crew | Art | Storyboard Artist | 3 |
 Dav Pilkey | Crew | Writing | Novel, Creator | 39 |
 Octavio E. Rodriguez | Crew | Directing | Director | 8 |
Daniel Dominguez | Crew | Writing | Writer | 9 |
Peter McCown | Crew | Production | Line Producer | 39 |
Matt Smith | Crew | Writing | Writer | 11 |
Seung Woo Cha | Crew | Directing | Director | 12 |
Todd Grimes | Crew | Directing | Director, Supervising Producer | 6 |
Jeff D'Elia | Crew | Writing | Writer | 4 |
Ian Young | Crew | Art | Storyboard Artist | 12 |
Erik Kling | Crew | Directing | Director | 4 |
Kyung-Soo Lee | Crew | Art | Storyboard Artist | 1 |
Sindy Boveda-Spackman | Crew | Writing | Writer | 10 |
Ryan Hansen | Crew | Art | Storyboard Artist | 3 |
Derek Moore | Crew | Art | Storyboard Artist | 1 |
 Clancy Brown | Cast | Actor | Mr. Ree / Splotch (voice) | 1 |
 David Koechner | Cast | Actor | Dr. Will Boryew (voice) | 1 |
 Dawn Wells | Cast | Actress | Gumbalina Toothington (voice) | 1 |
 Erica Luttrell | Cast | Actress | Erica / Plungerina (voice) | 1 |
 Fred Tatasciore | Cast | Actor | Furculees / Chief Hairococha (voice) | 1 |
 Jim Rash | Cast | Actor | Señor "Jerry" Citizen (voice) | 1 |
 John DiMaggio | Cast | Actor | Smelly Socktopus / Suds Latherman (voice) | 1 |
 Jorge Diaz | Cast | Actor | Melvin / Melvinborg (voice) | 39 |
 Kevin Michael Richardson | Cast | Actor | Diddly Saurus / The Schmoozer (voice) | 1 |
 Laraine Newman | Cast | Actress | Female Cop (voice) | 1 |
 Lewis Black | Cast | Actor | Ragely J. Snarlingtooth (voice) | 1 |
 Maggie Wheeler | Cast | Actress | Ms. Yewh / TP Mummy (voice) | 1 |
 Maurice LaMarche | Cast | Actor | Tubbadump (voice) | 1 |
 Mindy Sterling | Cast | Actress | Melvin's Mom (voice) | 2 |
 Nat Faxon | Cast | Actor | Captain Underpants / Mr. Krupp (voice) | 39 |
 Nolan North | Cast | Actor | Nanozero / Flash Flood (voice) | 1 |
 Paul Rugg | Cast | Actor | Vert Ladderfeller III / Altitooth / Bivouac Ladderfeller (voice) | 1 |
Peter Hastings | Cast | Actor | Papa Moneysack (voice) | 1 |
 Sean Astin | Cast | Actor | Pinches the Purple Penguin (voice) | 1 |
 Stephen Root | Cast | Actor | Mr. Fyde / Avacadwoe / Hush Muffleman (voice) | 1 |
 Steve-O | Cast | Actor | Lane Junkston (voice) | 1 |
 Thomas F. Wilson | Cast | Actor | Major Messy / Camoflush (voice) | 1 |
 Toby Huss | Cast | Actor | Caesar / Cruelius Sneezer (voice) | 1 |
 Tress MacNeille | Cast | Actress | Ms. Hurd (voice) | 1 |
 Trevor Devall | Cast | Actor | Smartsy Fartsy (voice) | 2 |
Tudi Roche | Cast | Actress | Bernice Krupp (voice) | 1 |
 Eric Bauza | Cast | Actor | Robius (voice) | 1 |
 Kari Wahlgren | Cast | Actress | Mayor Hoppy McChapper (voice) | 1 |
 Max Koch | Cast | Actor | Hank (voice) | 1 |
 Rob Riggle | Cast | Actor | Theodore "Ted" Murdsly (voice) | 1 |
 Dayci Brookshire | Cast | Jessica / Dressy (voice) | 39 | |
 Brennan Murray | Cast | Actor | Bo Hweemuth / Claylossus (voice) | 1 |
 Evan Kishiyama | Cast | Steve 'Gooch' Yamaguchi (voice) | 39 | |
 Ramone Hamilton | Cast | Actor | George (voice) | 39 |
 Jay Gragnani | Cast | Actor | Harold (voice) | 39 |
 Patty Mattson | Cast | Miss Anthrope / Clogneta (voice) | 1 | |
| Person | Type | Job | Role(s) | Episodes |
