| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 'Weird Al' Yankovic | Cast | Actor | Self | 1 |
 Adrian Grenier | Cast | Actor | Self | 1 |
 Al Gore | Cast | Actor | Self | 1 |
 Alan Alda | Cast | Actor | Self | 1 |
 Anna Deavere Smith | Cast | Actress | Self | 1 |
 Arianna Huffington | Cast | Actress | Self | 1 |
 Ben Stiller | Cast | Actor | Self | 1 |
 Bill Clinton | Cast | Actor | Self | 1 |
 Bill Maher | Cast | Actor | Self | 1 |
 Bill Nye | Cast | Actor | Self | 1 |
 Bill Prady | Cast | Actor | Self | 1 |
 Brian Greene | Cast | Actor | Self | 1 |
 Buzz Aldrin | Cast | Actor | Self | 1 |
 Christiane Amanpour | Cast | Actress | Self | 1 |
 Christopher Nolan | Cast | Actor | Self | 1 |
 Dan Rather | Cast | Actor | Self | 1 |
 Dan Savage | Cast | Actor | Self | 1 |
 Darren Aronofsky | Cast | Actor | Self | 1 |
 David Byrne | Cast | Actor | Self | 1 |
 David Crosby | Cast | Actor | Self | 1 |
 Frank Oz | Cast | Actor | Self | 1 |
 George R. R. Martin | Cast | Actor | Self | 1 |
 George Takei | Cast | Actor | Self | 1 |
 Herbie Hancock | Cast | Actor | Self | 1 |
 Jack Black | Cast | Actor | Self | 1 |
 James Cameron | Cast | Actor | Self | 1 |
 James Marsden | Cast | Actor | Self | 1 |
 Jane Goodall | Cast | Actress | Self | 1 |
 Jay Leno | Cast | Actor | Self | 1 |
 Jeff Goldblum | Cast | Actor | Self | 1 |
 Jeremy Irons | Cast | Actor | Self | 1 |
 Jimmy Carter | Cast | Actor | Self | 1 |
 Joe Rogan | Cast | Actor | Self | 1 |
 Kareem Abdul-Jabbar | Cast | Actor | Self | 1 |
 Katie Couric | Cast | Actress | Self | 1 |
 Kelly Slater | Cast | Actor | Self | 1 |
 Kevin Smith | Cast | Actor | Self | 1 |
 Lance Armstrong | Cast | Actor | Self | 1 |
 Larry Wilmore | Cast | Actor | Self | 1 |
 Mayim Bialik | Cast | Actress | Self | 1 |
 Norman Lear | Cast | Actor | Self | 1 |
 Patricia Cornwell | Cast | Actress | Self | 1 |
 Penn Jillette | Cast | Actor | Self | 1 |
 Seth MacFarlane | Cast | Actor | Self | 1 |
 Simon Helberg | Cast | Actor | Self | 1 |
 Stephen Colbert | Cast | Actor | Self | 1 |
 Stephen Hawking | Cast | Actor | Self | 1 |
 Susan Sarandon | Cast | Actress | Self | 1 |
 Teller | Cast | Actor | Self | 1 |
 Terry Crews | Cast | Actor | Self | 1 |
 Wayne Shorter | Cast | Actor | Self | 1 |
 Whoopi Goldberg | Cast | Actress | Self | 1 |
 William Shatner | Cast | Actor | Self | 1 |
 Anthony Bourdain | Cast | Actor | Self | 1 |
 Neil deGrasse Tyson | Cast | Actor | Self - Host | 76 |
 Richard Dawkins | Cast | Actor | Self | 1 |
 Sam Harris | Cast | Actor | Self | 1 |
 Sylvia Earle | Cast | Actress | Self | 1 |
 Brian Cox | Cast | Actor | Self | 1 |
 Fabien Cousteau | Cast | Actor | Self | 1 |
 Katy Perry | Cast | Actress | Self | 1 |
 Robert Kirkman | Cast | Actor | Self | 1 |
 Biz Stone | Cast | Actor | Self | 1 |
 Chris Hadfield | Cast | Actor | Self | 1 |
 Bas Lansdorp | Cast | Actor | Self | 1 |
 Hope Solo | Cast | Actress | Self | 1 |
 Scott Kelly | Cast | Actor | Self | 1 |
 Ashton Carter | Cast | Actor | Self | 1 |
 Charles Bolden | Cast | Self | 1 | |
| Person | Type | Job | Role(s) | Episodes |
