| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Kevin Phipps | Crew | Art | Art Direction | 54 |
 Patrick Stump | Crew | Sound | Original Music Composer, Main Title Theme Composer | 50 |
Steven L. Grover | Crew | Production | Supervising Producer | 50 |
Ashley Rideout | Crew | Production | Producer | 54 |
 Dee Bradley Baker | Cast | Actor | Trace-E / CAL (voice) | 1 |
 Eugene Byrd | Cast | Actor | Jefferson Morales (voice) | 6 |
 Fred Tatasciore | Cast | Actor | Devil Dinosaur (voice) | 1 |
 John Eric Bentley | Cast | Actor | Mr. Von Carnegie (voice) | 7 |
 John Stamos | Cast | Actor | Tony Stark / Iron Man (voice) | 6 |
 Justin Shenkarow | Cast | Actor | Aleksei Sytsevich / Rhino (voice) | 20 |
 Melique Berger | Cast | Mayor (voice) | 1 | |
 Thomas F. Wilson | Cast | Actor | William Baker / Sandman (voice) | 5 |
 Bindi Irwin | Cast | Actress | Isla Coralton (voice) | 1 |
 Kari Wahlgren | Cast | Actress | Helen Stacy (voice) | 6 |
 Melanie Minichino | Cast | Actress | Aunt May (voice) | 23 |
Patrick Stump | Cast | Actor | Concert Announcer (voice) | 1 |
 Scott Porter | Cast | Actor | George Stacy (voice) | 4 |
 Stephanie Lemelin | Cast | Actress | Francine Frye / Electro (voice) | 12 |
 JP Karliak | Cast | Actor | Norman Osborn / Green Goblin (voice) | 36 |
 Diamond White | Cast | Actress | Moon Girl / Lunella (voice) | 1 |
 Gabrielle Ruiz | Cast | Actress | Rio Morales (voice) | 6 |
 Sean Giambrone | Cast | Actor | Hank Pym / Ant-Man (voice) | 3 |
 Jakari Fraser | Cast | Actor | Miles Morales / Spider-Man (Spin) (voice) | 162 |
 Tru Valentino | Cast | Actor | T'Challa / Black Panther (voice) | 8 |
 Benjamin Valic | Cast | Actor | Peter Parker / Spider-Man (Spidey) (voice) | 164 |
