| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Frank Spotnitz | Crew | Writing | Story, Creator, Writer | 1 |
 Nicholas Meyer | Crew | Writing | Teleplay, Story, Writer, Creator | 1 |
 Sergio Mimica-Gezzan | Crew | Directing | Director | 7 |
 Emilia di Girolamo | Crew | Writing | Teleplay | 1 |
Francesca Gardiner | Crew | Writing | Teleplay | 1 |
Mark Denton | Crew | Writing | Teleplay | 1 |
Jonny Stockwood | Crew | Writing | Teleplay | 1 |
Alex von Tunzelmann | Crew | Writing | Screenplay | 1 |
Sophie Petzal | Crew | Writing | Screenplay | 1 |
 Alessandro Preziosi | Cast | Actor | Filippo Brunelleschi | 8 |
 Alessandro Sperduti | Cast | Actor | Piero de' Medici | 8 |
 Brian Cox | Cast | Actor | Bernardo Guadagni | 8 |
 Daniel Caltagirone | Cast | Actor | Andrea de' Pazzi | 8 |
 David Brandon | Cast | Actor | Petrucci | 13 |
 Dustin Hoffman | Cast | Actor | Giovanni de' Medici | 8 |
 Johnny Harris | Cast | Actor | Bruno Bernardi | 8 |
 Ken Bones | Cast | Actor | Ugo Bencini | 8 |
 Lex Shrapnel | Cast | Actor | Rinaldo Albizzi | 8 |
 Raoul Bova | Cast | Actor | Pope Sixtus IV | 6 |
 Richard Madden | Cast | Actor | Cosimo de' Medici | 8 |
 Sarah Parish | Cast | Actress | Lucrezia Tornabuoni | 8 |
 Sean Bean | Cast | Actor | 8 | |
 Valentina Cervi | Cast | Actress | Alessandra Ricco | 8 |
 Alessandra Mastronardi | Cast | Actress | Lucrezia Donati | 16 |
 Annabel Scholey | Cast | Actress | Contessina de' Medici | 13 |
 Antonio De Matteo | Cast | Actor | Claudio (Guard) | 1 |
 Daniel Sharman | Cast | Actor | Lorenzo de' Medici | 16 |
 Gualtiero Burzi | Cast | Actor | Fra Quintino | 8 |
 Guido Caprino | Cast | Actor | Marco Bello | 8 |
 Sarah Felberbaum | Cast | Actress | Maddalena | 8 |
 Bradley James | Cast | Actor | Giuliano de' Medici | 11 |
 Francesco Montanari | Cast | Actor | Girolamo Savonarola | 8 |
 Jack Roth | Cast | Actor | Girolamo Riario | 1 |
 Michael Schermi | Cast | Actor | Ricciardo | 8 |
 Miriam Leone | Cast | Actress | Bianca | 8 |
 Sebastian de Souza | Cast | Actor | Sandro Botticelli | 16 |
 Stuart Martin | Cast | Actor | Lorenzo de' Medici | 8 |
 Eugenio Franceschini | Cast | Actor | Ormanno degli Albizzi | 8 |
 Tatjana Nardone | Cast | Actress | Emilia | 8 |
 Edward Dring | Cast | Actor | Choirboy | 2 |
 Louis Partridge | Cast | Actor | Piero de' Medici | 4 |
 William Franklyn-Miller | Cast | Actor | Giovanni de' Medici | 4 |
 Matteo Martari | Cast | Actor | Francesco de' Pazzi | 8 |
 Valentina Bellè | Cast | Actress | Lucrezia Tornabuoni | 8 |
 Francesca Del Fa | Cast | Actress | Novella Foscari | 2 |
 Synnøve Karlsen | Cast | Actress | Clarice Orsini | 16 |
 Charlie Vickers | Cast | Actor | Guglielmo Pazzi | 8 |
 Sam Taylor Buck | Cast | Actor | Young Lorenzo | 5 |
 Nico Delpiano | Cast | Actor | Young Giovanni | 1 |
 Andrea Garofalo | Cast | Actor | Gianni | 4 |
| Person | Type | Job | Role(s) | Episodes |
