| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Adam Henry | Crew | Writing | Storyboard | 10 |
 Cathy Ladman | Crew | Writing | Story | 1 |
 Cree Summer | Crew | Sound | Theme Song Performance | 52 |
Dean Criswell | Crew | Directing | Director | 3 |
Denise Moss | Crew | Writing | Writer | 5 |
 Gábor Csupó | Crew | Creator | Creator | |
Jim Duffy | Crew | Directing | Director | 2 |
Joe Purdy | Crew | Writing | Writer, Story, Teleplay | 2 |
Lisa Albert | Crew | Writing | Writer | 1 |
 Mark Mothersbaugh | Crew | Sound | Original Music Composer | 52 |
Michael Daedalus Kenny | Crew | Directing | Director | 12 |
 Monica Piper | Crew | Writing | Story, Writer | 3 |
Norm Gunzenhauser | Crew | Writing | Writer | 8 |
 Paul Germain | Crew | Creator | Creator | |
 Robert Mothersbaugh | Crew | Sound | Original Music Composer | 52 |
Sharon Ross | Crew | Visual Effects | Visual Development | 12 |
Sheila M. Anthony | Crew | Writing | Writer | 8 |
Tom Frykman | Crew | Writing | Story | 1 |
 Erin Ehrlich | Crew | Writing | Story, Teleplay, Writer | 2 |
Peter Hunziker | Crew | Writing | Writer | 4 |
Ron Noble | Crew | Directing | Director | 16 |
Harry Harootunian | Crew | Writing | Idea | 1 |
Adam Cohen | Crew | Writing | Writer | 5 |
Scott Malchus | Crew | Writing | Idea | 1 |
John Enroth | Crew | Sound | Original Music Composer | 10 |
Denise Downer | Crew | Writing | Writer | 1 |
Zhenia Delioussine | Crew | Directing | Director | 8 |
 Krista Tucker | Crew | Writing | Story, Teleplay | 1 |
Scott Gray | Crew | Writing | Teleplay, Story, Writer | 2 |
 Silas Hite | Crew | Sound | Original Music Composer | 10 |
 Andrei Svislotski | Crew | Directing | Director | 14 |
 Alanna Ubach | Cast | Actress | Java Lava Boy (voice) | 1 |
 Ann Magnuson | Cast | Actress | Miss O'Keats (voice) | 7 |
 Bumper Robinson | Cast | Actor | Buster / Ty (voice) | 1 |
 Candi Milo | Cast | Actress | Brianna (voice) | 5 |
 Cara DeLizia | Cast | Actress | Z (voice) | 1 |
 Charles Shaughnessy | Cast | Actor | 1 | |
 Charlie Adler | Cast | Actor | Waiter (voice) | 1 |
 Cheryl Chase | Cast | Actress | Angelica Pickles (voice) | 52 |
 Christopher Neame | Cast | Actor | 1 | |
 Clancy Brown | Cast | Actor | Vice Principal Pangborn (voice) | 12 |
 Clive Revill | Cast | Actor | 1 | |
Cree Summer | Cast | Actress | Susie Carmichael (voice) | 52 |
 Crystal Scales | Cast | Actress | 1 | |
 Dan Bucatinsky | Cast | Actor | TV Doctor / Body Cast Man (voice) | 1 |
 Dan Castellaneta | Cast | Actor | Jonathan / Phone Caller / Sailing Instructor (voice) | 1 |
 Dee Bradley Baker | Cast | Actor | Parrot (voice) | 1 |
 Dionne Quan | Cast | Actress | Cool Boy #2 (voice) | 1 |
 Drake Bell | Cast | Actor | Teen Guy #3 (voice) | 1 |
 Elizabeth Daily | Cast | Actress | Laughing Student (voice) | 1 |
 Gina Gershon | Cast | Actress | 1 | |
 Glenn Shadix | Cast | Actor | 1 | |
 Greg Cipes | Cast | Actor | 1 | |
 Hattie Winston | Cast | Actress | Lucy Carmichael (voice) | 4 |
 Henry Gibson | Cast | Actor | 1 | |
 Hope Levy | Cast | Actress | Waitress (voice) | 1 |
 Howard Morris | Cast | Actor | Doctor (voice) | 1 |
 Jack Riley | Cast | Actor | Stu Pickles (voice) | 5 |
 Jason Ritter | Cast | Actor | Mr. Fisk (voice) | 1 |
 Jennifer Aquino | Cast | Actress | Chelsea / TV Nurse (voice) | 1 |
 Jennifer Hale | Cast | Actress | Brett / Diane (voice) | 1 |
 Jess Harnell | Cast | Actor | 1 | |
 Jesse Corti | Cast | Actor | 1 | |
 Jessica DiCicco | Cast | Actress | 2 | |
 Jim Meskimen | Cast | Actor | Skeleton / Dr. Cartunian / Dr. Cartunian Sr. (voice) | 1 |
 Joe Alaskey | Cast | Actor | Grandpa Lou Pickles (voice) | 1 |
 Julia Kato | Cast | Kira Watanabe-Finster (voice) | 1 | |
 Kath Soucie | Cast | Actress | Betty DeVille / Beverly Jones (voice) | 1 |
 Ken Page | Cast | Actor | 1 | |
 Lane Toran | Cast | Actor | 1 | |
 Laraine Newman | Cast | Actress | Samantha Shane / Clerk (voice) | 1 |
 Lauren Tom | Cast | Actress | 1 | |
 Leslie Carrara-Rudolph | Cast | Actress | 1 | |
 Matt Vasgersian | Cast | Actor | 1 | |
 Melanie Chartoff | Cast | Actress | Didi Pickles (voice) | 4 |
 Michael Bell | Cast | Actor | Chaz Finster / Drew Pickles / Boris (voice) | 1 |
 Michael Dorn | Cast | Actor | 1 | |
 Michael Horse | Cast | Actor | 1 | |
 Nancy Cartwright | Cast | Actress | Chuckie Finster (voice) | 52 |
 Ogie Banks | Cast | Actor | Edwin (voice) | 2 |
 Pamela Adlon | Cast | Actress | Sean Butler (voice) | 6 |
 Pat Musick | Cast | Actress | Edith (voice) | 1 |
 Phil Proctor | Cast | Actor | Howard DeVille (voice) | 1 |
Romeo | Cast | Actor | Li'l Q (voice) | 1 |
 Ron Glass | Cast | Actor | Randy Carmichael (voice) | 4 |
 Scott Menville | Cast | Actor | 1 | |
Shayna Fox | Cast | Actress | Savannah Shane (voice) | 2 |
 Tara Strong | Cast | Actress | Cool Boy #1 (voice) | 1 |
 Tom Kenny | Cast | Actor | 1 | |
 Tress MacNeille | Cast | Actress | Charlotte Pickles (voice) | 2 |
 Wally Wingert | Cast | Actor | 1 | |
 Charles Duckworth | Cast | Actor | Fridge (voice) | 1 |
 Kate Higgins | Cast | Actress | Leslie (voice) | 1 |
 Bettina Bush | Cast | Actress | Alisa (voice) | 1 |
 Fred Stoller | Cast | Actor | Mr. Beaker (voice) | 1 |
 Rory Thost | Cast | Actor | 1 | |
 Philece Sampler | Cast | Actress | Francine (voice) | 1 |
Lizzie Murray | Cast | Nicole Boscarelli (voice) | 2 | |
 Angelique Perrin | Cast | Paris (voice) | 4 | |
Denise Pickering | Cast | Rachel (voice) | 1 | |
 Rosslynn Taylor Jordan | Cast | Actress | Girl #2 / Computer (voice) | 1 |
| Person | Type | Job | Role(s) | Episodes |
