| Person | Type | Job | Role(s) |
|---|---|---|---|
 Adam Henry | Crew | Directing | Layout |
Albie Hecht | Crew | Production | Executive Producer |
 Arlene Klasky | Crew | Production | Producer |
Barry Atkinson | Crew | Art | Art Direction |
Brice Mallier | Crew | Visual Effects | Visual Effects |
Dima Malanitchev | Crew | Art | Production Design |
 Eryk Casemiro | Crew | Production | Executive Producer |
Frans Vischer | Crew | Crew | Sequence Supervisor |
 Gábor Csupó | Crew | Production | Producer |
 Greg Tiernan | Crew | Crew | Sequence Supervisor |
Howard E. Baker | Crew | Crew | Sequence Supervisor |
Jay Jackson | Crew | Directing | Layout |
 John Bryant | Crew | Editing | Editor |
 Julia Pistor | Crew | Production | Executive Producer |
 Kate Boutilier | Crew | Writing | Writer |
Larry White | Crew | Visual Effects | Animation |
Marco Cinello | Crew | Art | Background Designer |
 Mark Mothersbaugh | Crew | Sound | Original Music Composer |
Norton Virgien | Crew | Directing | Director |
 Priit Pärn | Crew | Directing | Co-Director |
Roberto Casale | Crew | Visual Effects | Animation |
Sharon Ross | Crew | Art | Art Department Manager |
Silvia Pompei | Crew | Directing | Layout |
Tracy Kramer | Crew | Production | Co-Producer |
Beth S. Morris | Crew | Crew | Technical Supervisor |
Heiko von Drengenberg | Crew | Directing | Layout |
Jim Ovelmen | Crew | Visual Effects | Animation, Visual Effects |
José Antonio García Villameriel | Crew | Visual Effects | Visual Effects |
Leonard F.W. Green | Crew | Visual Effects | Visual Effects |
Louie C. Jhocson | Crew | Visual Effects | Animation Manager |
Rick Moser | Crew | Crew | Technical Supervisor |
John Eng | Crew | Directing | Director |
Terry Thoren | Crew | Production | Co-Producer |
Hal Waite | Crew | Production | Executive Producer |
Kimberly Rettberg | Crew | Editing | Editor |
 Bruce Willis | Cast | Actor | Spike (voice) |
 Cheryl Chase | Cast | Actress | Angelica Pickels (voice) |
 Chrissie Hynde | Cast | Actress | Siri (voice) |
 Cree Summer | Cast | Actress | Susie Carmichael (voice) |
 Danielle Harris | Cast | Actress | Debbie Thornberry (voice) |
 Dionne Quan | Cast | Actress | Kimi Watanabe-Finster (voice) |
 Elizabeth Daily | Cast | Actress | Tommy Pickles (voice) |
 Ethan Phillips | Cast | Actor | Toa (voice) |
 Flea | Cast | Actor | Donnie Thornberry (voice) |
 Jack Riley | Cast | Actor | Stuart 'Stu' Pickles (voice) |
 Jodi Carlisle | Cast | Actress | Marianne Thornberry (voice) |
 Joe Alaskey | Cast | Actor | Lou Pickles (voice) |
 Julia Kato | Cast | Kira Watanabe-Finster (voice) | |
 Kath Soucie | Cast | Actress | Phil DeVille / Lil DeVille / Betty DeVille (voice) |
 Lacey Chabert | Cast | Actress | Eliza Thornberry (voice) |
 Melanie Chartoff | Cast | Actress | Didi Pickles (voice) |
 Michael Bell | Cast | Actor | Drew Pickles / Charles 'Chaz' Finster, Sr. (voice) |
 Nancy Cartwright | Cast | Actress | Chuckie Finster (voice) |
 Phil Proctor | Cast | Actor | Howard DeVille (voice) |
 Tara Strong | Cast | Actress | Dil Pickles (voice) |
 Tim Curry | Cast | Actor | Nigel Thornberry (voice) |
 Tom Kane | Cast | Actor | Darwin (voice) |
 Tony Jay | Cast | Actor | Dr. Lipschitz (voice) |
 Tress MacNeille | Cast | Actress | Charlotte Pickles (voice) |
| Person | Type | Job | Role(s) |
