| Person | Type | Job | Role(s) |
|---|---|---|---|
 Bruce Gowers | Crew | Directing | Director |
 Bryan Loftus | Crew | Camera | Director of Photography |
 David Fincher | Crew | Directing | Director |
 Herb Ritts | Crew | Directing | Director, Director of Photography |
 James Foley | Crew | Writing | Writer, Director |
 Jean-Baptiste Mondino | Crew | Directing | Director |
 Jordan Cronenweth | Crew | Camera | Director of Photography |
 Keith Williams | Crew | Writing | Writer |
 Madonna | Crew | Writing | Writer, Songs |
Mark Plummer | Crew | Camera | Director of Photography |
 Mary Lambert | Crew | Directing | Director |
 Michael Ballhaus | Crew | Camera | Director of Photography |
Michele Ferrone | Crew | Directing | Director |
 Patrick Leonard | Crew | Sound | Songs |
Peter Rafelson | Crew | Sound | Songs |
Peter Sinclair | Crew | Camera | Director of Photography |
 Stephen Bray | Crew | Sound | Songs |
 Steven Poster | Crew | Camera | Director of Photography |
 Wayne Isham | Crew | Camera | Director of Photography |
Pascal Lebègue | Crew | Camera | Director of Photography |
Gardner Cole | Crew | Sound | Songs |
 Reggie Lucas | Crew | Sound | Songs |
Andrea Dietrich | Crew | Camera | Director of Photography |
Peter H. Brown | Crew | Sound | Songs |
 Billy Steinberg | Crew | Sound | Songs |
Arthur Pierson | Crew | Directing | Director |
Tom Kelly | Crew | Sound | Songs |
Bruce Gaitsch | Crew | Sound | Songs |
Robert Rans | Crew | Sound | Songs |
Shep Pettibone | Crew | Sound | Songs |
Brian Elliot | Crew | Sound | Songs, Writer |
 Alex McArthur | Cast | Actor | Boyfriend (segment "Papa Don't Preach") |
 Benicio del Toro | Cast | Actor | Kid Sitting on Car (segment "La Isla Bonita") |
 Carlton Wilborn | Cast | Actor | Voguer (segment "Vogue") |
Christopher Ciccone | Cast | Actor | Dancer (segment "Lucky Star") |
 Danny Aiello | Cast | Actor | Papa (segment "Papa Don't Preach") |
 Debi Mazar | Cast | Actress | Friend (segment "Papa Don't Preach") |
 Deke Anderson | Cast | The Director (segment "Material Girl") | |
 Donna DeLory | Cast | Actress | Voguer (segment "Vogue") |
 Gustav Vintas | Cast | Prison Wardon (segment "Express Yourself") | |
 John Leguizamo | Cast | Actor | Friend of Boyfriend (segment "Borderline") |
 Keith Carradine | Cast | Actor | Boyfriend (segment "Material Girl") |
 Kevin Stea | Cast | Actor | Voguer (segment "Vogue") |
 Leon | Cast | Actor | Innocent Man / Saint (segment "Like a Prayer") |
Luis Camacho | Cast | Voguer (segment "Vogue") | |
Madonna | Cast | Actress | Self |
 Mailon Rivera | Cast | Actor | Friend (segment "Papa Don't Preach") |
 Niki Haris | Cast | Actress | Voguer (segment "Vogue") |
 Robert Wuhl | Cast | Actor | Pitch Man (segment "Material Girl") |
 Salim Gauwloos | Cast | Actor | Voguer (segment "Vogue") |
 Todd Gordon | Cast | Factory Worker (segment "Express Yourself") | |
 Tony Ward | Cast | Actor | Merman (segment "Cherish") |
Sharon Oreck | Cast | Woman in clown costume (segment "Material Girl") | |
Oliver Crumes Jr. | Cast | Voguer (segment "Vogue") | |
Gabriel Trupin | Cast | Actor | Voguer (segment "Vogue") |
Louie Louie | Cast | Actor | Boyfriend (segment "Borderline") |
 Felix Howard | Cast | Actor | Kid (segment "Open Your Heart") |
Erika Belle | Cast | Dancer (segment "Lucky Star") (segment "Papa Don't Preach") | |
Jose Guitierez | Cast | Voguer (segment "Vogue") | |
Mark Romano | Cast | Father (segment "Oh Father") | |
Cameron Alborzian | Cast | Actor | Man (segment "Express Yourself") |
| Person | Type | Job | Role(s) |
