| Person | Type | Job | Role(s) |
|---|---|---|---|
 John Holmquist | Crew | Directing | Director |
 Greg Colton | Crew | Directing | Director |
 Adam West | Cast | Actor | Mayor Adam West (voice) |
 Alex Borstein | Cast | Actress | Lois Griffin (voice) |
 Alexandra Breckenridge | Cast | Actress | Cancer Sufferer (voice) (as Alex Breckenridge) |
 David Anthony Pizzuto | Cast | Actor | Willem Dafoe (voice) |
 Mila Kunis | Cast | Actress | Meg Griffin (voice) |
 Patrick Stewart | Cast | Actor | Avery Bullock (voice) |
 Patrick Warburton | Cast | Actor | Joe Swanson (voice) |
 Paula Abdul | Cast | Actress | Herself (voice) |
 Phil LaMarr | Cast | Actor | Judge (voice) |
 Seth Green | Cast | Actor | Chris Griffin (voice) |
 Seth MacFarlane | Cast | Actor | Peter Griffin / Stewie Griffin / Stan Smith (voice) |
 David Boat | Cast | Actor | Rupert (voice) |
 Mike Henry | Cast | Actor | Cleveland Brown / Bruce / Jeffry / Consuela (voice) |
 Randy Jackson | Cast | Actor | Himself (voice) |
 Simon Cowell | Cast | Actor | Himself (voice) |
| Person | Type | Job | Role(s) |
