| Person | Type | Job | Role(s) |
|---|---|---|---|
 Alisa Christensen | Crew | Crew | Fight Choreographer |
 Brendan Flynt | Crew | Camera | Director of Photography |
 Caleb Emerson | Crew | Production | Casting |
Gabriel Friedman | Crew | Writing | Screenplay, Editor |
Geoff Mosher | Crew | Production | Casting |
James Coleman | Crew | Production | Executive Producer |
 Lloyd Kaufman | Crew | Directing | Director, Producer, Screenplay |
 Matt Levin | Crew | Crew | Additional Writing |
 Michael Herz | Crew | Production | Producer |
 Orson Welles | Crew | Crew | Thanks |
Patrick Cassidy | Crew | Writing | Screenplay, Line Producer |
 Trent Haaga | Crew | Production | Line Producer, Casting, Screenplay |
Wanda Harris | Crew | Production | Casting |
Wes Nagy | Crew | Sound | Original Music Composer |
 Will Keenan | Crew | Production | Casting |
Alison Grossman | Crew | Art | Production Design |
Corey Kalman | Crew | Crew | Additional Writing |
Andrew Lerner | Crew | Production | Executive Producer |
 Yoni Tabac | Crew | Production | Associate Producer |
Ken Squire | Crew | Production | Executive Producer |
Weston Quasha | Crew | Production | Executive Producer |
Sean Collins | Crew | Crew | Additional Writing |
 Al Goldstein | Cast | Actor | Press Secretary |
Barry Brisco | Cast | Pompey | |
 Charlotte Kaufman | Cast | Actress | Tromaville / Amortville Citizen |
Clyde Lewis | Cast | Actor | Toxie (voice) |
 Corey Feldman | Cast | Actor | Sarah's Gynecologist |
 David Mattey | Cast | Actor | Toxic Avenger / Noxious Offender |
 Debbie Rochon | Cast | Actress | Ms. Weiner |
 Devin DeVasquez | Cast | Actress | Glamorous Gyno-American |
 Doria Rone | Cast | Actress | Glamorous Gyno-American |
 Eli Roth | Cast | Actor | Beautiful Young Boy |
 Hank the Angry Drunken Dwarf | Cast | Actor | God |
Heidi Sjursen | Cast | Actress | Sarah / Claire |
 Hugh Hefner | Cast | Actor | President of the United States |
 James Gunn | Cast | Actor | Dr. Flem Hocking |
 Jasi Cotton Lanier | Cast | Actress | Wet Lesbian |
 Jason Sklar | Cast | Actor | Jason Gonzalez |
 Joe Fleishaker | Cast | Actor | Chester / Lardass |
 Julie Strain | Cast | Actress | Herself (Facelift Death) |
 Kevin Eastman | Cast | Actor | Himself (Breast Smoosh Death) |
 Lemmy Kilmister | Cast | Actor | Good Lemmy / Bad Lemmy |
 Lisa Gaye | Cast | Actress | Abortion Counselor |
Lisa Terezakis | Cast | Sweetie Honey | |
Lloyd Kaufman | Cast | Actor | Man in Public Service Announcement |
 Mark Torgl | Cast | Actor | Evil Melvin |
Melissa Bacelar | Cast | Actress | Dr. Hocking's Nurse |
Michael Budinger | Cast | Tito | |
 Mitch Cohen | Cast | Actor | Lucifer |
Paul Kyrmse | Cast | Actor | Sgt. Kabukiman / Evil Kabukiman |
 Petra Verkaik | Cast | Actress | Glamorous Gyno-American |
 Randy Sklar | Cast | Actor | Randy Diaz |
 Rick Collins | Cast | Actor | Amortville Police Chief |
 Ron Jeremy | Cast | Actor | Mayor Goldberg |
 Stan Lee | Cast | Actor | Prologue / Epilogue Narrator |
 Taimie Hannum | Cast | Actress | Glamorous Gyno-American |
 Taylor Mead | Cast | Actor | Award Presenter |
 Tiffany Shepis | Cast | Actress | Beautiful Interpretative Dancer |
 Tom Fulp | Cast | Actor | Painter |
Trent Haaga | Cast | Actor | Tex Diaper |
Will Keenan | Cast | Actor | Man Hit by Car |
Yaniv Sharon | Cast | Actor | Rex Diaper |
 Masuimi Max | Cast | Actress | Glamorous Gyno-American |
 Neriah Davis | Cast | Actress | Glamorous Gyno-American |
 Dan Snow | Cast | Sgt. Kazinski | |
 Brandi Brandt | Cast | Actress | Glamorous Gyno-American |
 Celeste Octavia | Cast | Actress | Glamorous Gyno-American / Naked Nurse (as Celeste Octavian) |
Tromelissa Saytar | Cast | Lesbian Art Student | |
Terri Firmer | Cast | Wet Lesbian / Topless Deaf Translator | |
Bella Compagna | Cast | Actress | Diaper Mafia Temptress |
| Person | Type | Job | Role(s) |
